Whoever"s behind the newspaper of Apocryphal Chemistry is do the efforts to execute everyone a good deed prior to we acquire into allergy season. After detailing the ever-more-stringent controls ~ above the sale of pseudephedrine, they suggest a fabricated route based on a an ext readily available starting material: methamphetamine.A quick search of several neighborhoods of the United claims revealed that while pseudephedrine is challenging to obtain, N-methylmethamphetamine can be procured at nearly any time on short an alert and in quantities enough for synthesis of useful amounts of the preferred material. Moreover, follow to federal government statistics, N-methylmethamphetamine is becoming an significantly attractive beginning material because that pseudephedrine, together the availability of N-methylmethamphetamine has remained high while prices have dropped and also purity has increased. We present here a convenient series of transformations using reagents which can be found in most well stocked essential chemistry laboratories. . .1985 record in J. Chem. Soc. Chem. Comm., is not exactly trailer-park chemistry, though. (I note that they have actually the reference a little bit wrong as well; there was no level J. Chem. Soc. In 1985). It entails a chromium carbonyl complicated of the aryl ring, formation of a chiral lithium dianion, and also oxidation that that v MoOPH, i beg your pardon would give you pseudephedrine after ~ decomplexation. There"s no method to phone call if this reactions have actually actually to be run, that course. Based on the literary works precedent, it could work, return I"d be worried around maintaining the chirality the the dianion. (For what it"s worth, the writer are likewise aware that this problem, and claim the the selectivity to be unaffected).Their larger allude stands. I look front to seeing an ext from this paper"s authors, O. Hai and I. B. Hakkenshit. I watch less amazing stuff in my RSS feeding every day of the week.

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Derek Lowe

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Derek Lowe, an Arkansan through birth, obtained his BA native Hendrix College and his phd in necessary chemistry from Duke prior to spending time in Germany on a Humboldt Fellowship top top his post-doc. He’s operated for several significant pharmaceutical companies due to the fact that 1989 on drug exploration projects against schizophrenia, Alzheimer’s, diabetes, osteoporosis and also other diseases.


Derek Lowe"s comment on drug discovery and the pharma industry. An editorially independent blog, all content is Derek’s own, and also he does no in any means speak because that his employer.