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Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002.

By agreement with the publisher, this book is obtainable by the find feature, however cannot it is in browsed.



Having gene in typical accounts for the resemblance of a mother and herdaughters. Genes have to be expressed to exert an effect, and also proteins control suchexpression. One such regulatory protein, a zinc-finger protein (zinc ion isblue, protein is red), (more...)

DNA and RNA are long straight polymers, called nucleic acids, that carry information ina type that deserve to be passed native one generation come the next. These macromoleculesconsist that a huge number of linked nucleotides, each written of a sugar, aphosphate, and a base. Sugars attached by phosphates kind a common backbone, whereasthe bases vary amongst four kinds. Genetic information is save on computer in thesequence of bases follow me a nucleic mountain chain. The bases have actually anadditional one-of-a-kind property: they form specific pairs through one another that arestabilized by hydrogen bonds. The base pairing results in the development of a doublehelix, a helical framework consisting of two strands. These base pairsprovide a mechanism for copying the hereditary information in an existing nucleicacid chain to type a new chain. Back RNA probably operated as thegenetic material really early in evolution history, the genes of all modern-day cellsand numerous viruses are made that DNA. DNA is replicated by the action of DNA polymeraseenzymes. This exquisitely details enzymes copy assignment from main point acidtemplates v an error rate of much less than 1 in 100 million nucleotides.

Genes specify the kinds of proteins that room made by cells, yet DNA is not the directtemplate for protein synthesis. Rather, the templates for protein synthesis are RNA(ribonucleic acid) molecules. In particular, a course of RNA molecule calledmessenger RNA (mRNA) are the information-carrying intermediatesin protein synthesis. Other RNA molecules, together as transport RNA(tRNA) and ribosomal RNA (rRNA), are part of theprotein-synthesizing machinery. All develops of to move RNA room synthesized by RNApolymerases the take instructions native DNA templates. This procedure oftranscription is adhered to by translation, thesynthesis of protein according to instructions provided by mRNA templates. Thus, theflow of hereditary information, or gene expression, in common cellsis:


This circulation of information is dependent on the hereditary code, which specifies the relationbetween the succession of bases in DNA (or that mRNA transcript) and the succession ofamino mountain in a protein. The password is virtually the same in all organisms: a sequenceof three bases, called a codon, specifies an amino acid. Codons inmRNA are check out sequentially by tRNA molecules, which offer as adaptors in proteinsynthesis. Protein synthesis takes location on ribosomes, i m sorry are complicated assembliesof rRNAs and much more than 50 type of proteins.

The last template to be thought about is the interrupted character of most eukaryoticgenes, which are mosaics that nucleic mountain sequences dubbed intronsand exons. Both room transcribed, but introns are reduced out the newlysynthesized RNA molecules, leaving mature RNA molecules with constant exons. Theexistence of introns and also exons has crucial implications for the development ofproteins.

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5.1. A main point Acid consists of 4 Kinds the Bases linked to a Sugar-Phosphate Backbone5.2. A Pair of Nucleic mountain Chains v Complementary assignment Can kind a Double-Helical Structure5.3. DNA Is Replicated through Polymerases the Take Instructions indigenous Templates5.4. Gene Expression Is the change of DNA details Into sensible Molecules5.5. Amino Acids room Encoded by groups of 3 Bases beginning from a fixed Point5.6. Many Eukaryotic Genes are Mosaics that Introns and ExonsSummaryProblemsSelected Readings

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